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Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are inside the live-action ones: the film is set in a fictionalized version of the human body which resembles a large city, where micro-organisms or any being based in organisms are anthropomorphic and centers on Frank Detorre, a slovenly zookeeper. Osmosis "Ozzy" Jones, a white blood cell, teams up with Drix, a cold pill, against Thrax, a deadly virus who plans to kill Frank in forty-eight hours and other characters living within him. The film was met with mixed reviews, and earned $14 million against a budget of $70 million. Despite the lack of accolades, it sold well in home media. It also served as the pilot to the Kids' WB television series Ozzy & Drix (2002–04), wherein Ozzy and Drix get transferred by a mosquito to the body of a teenage boy named Hector, and continue their battle against germs and viruses from there.
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